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​Publications 
学術論文

​01//超音波非侵襲温度測定技術

Open Access

がん温熱治療中の腫瘍組織内温度上昇を本研究グループが

開発した超音波散乱波統計解析技術によって画像化に成功

しました(臨床試験)

M. Takeuchi, T. Sakai, G. Andocs, T. Takanaka, M. Taka, K.

Yamashita, M. Kawahara, T. Nojiri, A. Tanaka, A. Norishima,

Y. Omoto, M. Omura, R. Nagaoka, K. Takao, and

H. Hasegawa.

Statistical Analysis of Ultrasonic Scattered Echoes

Enables the Noninvasive Measurement of

Temperature Elevations  inside Tumor Tissue

during Oncological Hyperthermia. 

Ultrasound Med. Biol. 47, 3301 (2021).

https://doi.org/10.1016/j.ultrasmedbio.2021.07.019

本研究グループが用いている超音波散乱波統計解析による

生体内温度上昇測定手法のメカニズムの詳細をコンピュータ

シミュレーションで明らかにしました

M. Omura, M. Takeuchi, R. Nagaoka, and H. Hasegawa.

A study on understanding the physical mechanism of

change in ultrasonic envelope statistical property

during temperature elevation.

Med. Phys. 48, 3041 (2021).

https://doi.org/10.1002/mp.14890

Open Access

ラジオ波で加熱されたラットの腫瘍組織内温度上昇を超音波

散乱波統計解析技術で可視化に成功しました

M. Takeuchi, T. Sakai, G. Andocs, K. Takao, R. Nagaoka,

and H. Hasegawa. Temperature elevation in tissue

detected in vivo based on statistical analysis of

ultrasonic scattered echoes.

Sci. Rep. 10, 9030 (2020).

https://doi.org/10.1038/s41598-020-65562-4

超音波散乱波統計解析から得られるパラメータを鋭敏化し

生体試料内僅かな温度勾配(5℃以下)を画像化する手法

を開発しました

M. Takeuchi, Y. Matsui, T. Sakai, G. Andocs, R. Nagaoka,

and H. Hasegawa. Investigation of initial value

dependence in the statistical analysis of ultrasonic

scattered echoes for the non-invasive estimation of temperature distribution  in biological tissue.

Jpn. J. Appl. Phys. 58, SGGE09 (2019).

https://doi.org/10.7567/1347-4065/ab0ba8

超音波散乱波統計解析によって生体試料内の温度上昇を

非侵襲的に測定出来ることを報告しました

M. Takeuchi, Y. Matsui, T. Doi, Y. Takano, G. Andocs, and

H. Hasegawa. Measurement of internal temperature in

biological tissue specimen with deformation by

statistical analysis of ultrasonic scattered echoes. 

Jpn. J. Appl. Phys. 57, 07LB17 (2018).

https://doi.org/10.7567/JJAP.57.07LB17

​02//オンコサーミア

”オンコサーミア”(Modulated Electro-hyperthermia)の

現状と将来展望
MASAHIKO KANAMORI, TSUTOMU SATO, TOMOKO SHIMA,

JUN-ICHI SAITOH, GABOR ANDOCS, TAKASHI KONDO
“Oncothermia” (Modulated electro-hyperthermia)

- Present status and future development - 

Thermal Med, 37 (1): 1-14, 2021.
https://www.jstage.jst.go.jp/article/thermalmed/37/1/37_1/_article/-char/ja/

進行性転移乳がんへのオンコサーミア臨床試験
Takuya Nagata Masahiko Kanamori Shinichi Sekine Mie Arai Makoto Moriyama Tsutomu Fujii
Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer
Molecular and Clinical Oncology :  March 17, 2021

https://doi.org/10.3892/mco.2021.2265
02//​脳腫瘍治療とオンコサーミア
再発悪性神経膠芽腫と星状細胞腫の統合治療における
オンコサーミア:後向き多施設比較試験
Giammaria Fiorentini, Donatella Sarti, Carlo Milandri,
Patrizia Dentico, Andrea Mambrini, Caterina Fiorentini,
Gianmaria Mattioli, Virginia Casadei and Stefano Guadagni
Modulated Electrohyperthermia in Integrative Cancer
Treatment for Relapsed Malignant Glioblastoma and Astrocytoma: Retrospective Multicenter Controlled Study
Integr Cancer Ther. Jan-Dec 2019

https://journals.sagepub.com/doi/10.1177/1534735418812691
オンコサーミアの再発悪性神経膠腫に対する後ろ向き
フェーズII試験
E.D. HagerH.SahinbasD.H.GroenemeyerF. Migeod
Prospective phase II trial for recurrent high-grade
gliomas with capacitive coupled low radiofrequency
(LRF) hyperthermia 
Journal of Clinical Oncology 26, no. 15_suppl
(May 20, 2008) 2047-2047.

https://ascopubs.org/doi/abs/10.1200/jco.2008.26.15_suppl.2047
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